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Hi folks, I've been trying out combining NMN with NR for the past few months and to be honest the effects are pretty impressive - my energy levels are much better and I'm sleeping deeper than I have in years! Based on my research, NMN and NR work through separate mechanisms to increase NAD+ levels, with nicotinamide riboside utilizing the NRK1 NRK2 enzymes while NMN potentially bypasses some conversion steps via the direct transport mechanism. I'm taking NMN 500mg in the early AM with 250mg NR and adding resveratrol for synergy to maintain higher NAD+ - the combination seems way more powerful than taking either precursor individually. Anyone else noticed better results from
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I've been experimenting with an NMN NR combination for about three months now and I have to say the synergistic effect seems way more effective than taking either compound alone - apparently nicotinamide mononucleotide uses the direct pathway while NR goes through a different conversion process so you're basically hitting your NAD+ levels from different pathways which makes sense since age-related NAD+ loss is such a huge problem in declining energy production and I'm definitely noticing less fatigue plus enhanced recovery especially when I add in quercetin as a CD38 inhibitor - other people tried this dual precursor method and what amounts are you using because I'm currently doing NMN 500mg plus NR 500mg in the early morning routine but wondering if the schedule affects bioavailability for maximum cellular health benefits?
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